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Publikationen Prof. Dr. Josef Rüschoff
Publikationen 2000-2003

Bilous, M., Dowsett, M., Hanna, W., Isola, J., Lebeau, A., Moreno, A., Penault-Llorca, F., Rüschoff, J., Tomasic, G., Van De Vijver, M. (2003) Current Perspectives on HER2 Testing: A Review of National Testing Guidelines. Mod. Pathol. 16(2):173-82.

Schonberger, J., Rüschoff, J., Grimm, D., Marienhagen, J., Rummele, P., Meyringer, R., Kossmehl, P., Hofstaedter, F. and Eilles, C. (2002) Glucose transporter 1 gene expression is related to thyroid neoplasms with an unfavorable prognosis: an immunohistochemical study. Thyroid. 12(9):747-54.

Hartmann, A., Zanardo, L., Bocker-Edmonston, T., Blaszyk, H., Dietmaier, W., Stoehr, R., Cheville, J.C., Junker, K., Wieland, W., Knuechel, R., Rüschoff, J., Hofstaedter, F. and Fishel, R. (2002) Frequent microsatellite instability in sporadic tumors of the upper urinary tract. Cancer Res. 62(23):6796-802.

Muller, A., Edmonston, T.B., Corao, D.A., Rose, D.G., Palazzo, J.P., Becker, H., Fry, R.D., Rüschoff, J. and Fishel, R. (2002) Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. Cancer Res. 62(4):1014-9.

Lechner, S., Muller-Ladner, U., Schlottmann, K., Jung, B., McClelland, M., Rüschoff, J., Welsh, J., Scholmerich, J. and Kullmann, F. (2002) Bile acids mimic oxidative stress induced upregulation of thioredoxin reductase in colon cancer cell lines. Carcinogenesis. 23(8):1281-8.

Fogt, F., Beyser, K.H., Poremba, C., Zimmerman, RL., Khettry, U. and Rüschoff, J. (2002) Recipient-derived hepatocytes in liver transplants: a rare event in sex-mismatched transplants. Hepatology. 36(1):173-6.

Ruckert, S., Hiendlmeyer, E., Brueckl, W.M., Oswald, U., Beyser, K., Dietmaier, W., Haynl, A., Koch, C., Rüschoff, J., Brabletz, T., Kirchner, T. and Jung, A. (2002) T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis. Cancer Res. 62(11):3009-13.

Langner, C., Homayounfar, K., Ruten, B., Fass, J. and Rüschoff, J. (2001) Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver Pathologe. 22(6):417-23.

Faller, G., Berndt, R., Borchard, F., Ell, C., Fuchs, K.H., Geddert, H., Gossner, L., Gunther, T., Kirchner, T., Koch, H.K., Langner, C., Luttges, J., May, A., Muller, S., Oberhuber, G., Seitz, G., Stolte, M., Tannapfel, A., Vieth, M., Walch, A. and Rüschoff, J. (2003) Histopathological diagnosis of Barrett's mucosa and associated neoplasias. Results of a consensus conference of the Working Group for "Gastroenterological Pathology of the German Society for Pathology" on 22 September 2001 Pathologe. 24(1):9-14.

Langner, C., Dorlars, D., Gross, C. and Rüschoff J. (2001) Acute segmental hemorrhagic antibiotic-associated colitis Pathologe. 22(5):339-42.

Lechner, S., Muller-Ladner, U., Neumann, E., Dietmaier, W., Welsh, J., Scholmerich, J., Rüschoff, J. and Kullmann, F. (2001) Use of simplified transcriptors for the analysis of gene expression profiles in laser-microdissected cell populations.
Lab Invest. 81(9):1233-42.

Kullmann, F., Messmann, H., Alt, M., Gross, V., Bocker, T., Scholmerich, J. and Rüschoff, J. (2001) Clinical and histopathological features of dextran sulfate sodium induced acute and chronic colitis associated with dysplasia in rats. Int. J. Colorectal Dis. 16(4):238-46.

Langner, C., Hoffmann, J.G., de Geeter, P., Rompel, R. and Rüschoff, J. (2001) Pigmented pheochromocytoma. Case report with immunohistochemical and electron microscopic characterization Pathologe. 22(4):276-80.

Barth, G., Basten, O., Rüschoff, J. and Rompel, R. (2001) Clinical and histopathological characteristics of early Leser-Trelat syndrome

Hautarzt. 52(7):649-52.

Meier, M., Weng, L.P., Alexandrakis, E., Rüschoff, J. and Goeckenjan, G. (2001) Tracheobronchial stenosis in Keutel syndrome. Eur. Respir. J. 17(3):566-9.

Dietmaier, W., Gansbauer, S., Beyser, K., Renke, B., Hartmann, A., Rummele, P., Jauch, K.W., Hofstadter, F. and Rüschoff, J. (2000) Microsatellite instability in tumor and nonneoplastic colorectal cells from hereditary non-polyposis colorectal cancer and sporadic high microsatellite-instable tumor patients. Pathobiology. 68(4-5):227-31.

Kolble, K., Barthel, B., Ullrich, O., Pidde, H., Dohring, C., Rüschoff, J., Schlag, P.M. and Dietel, M. (2000) beta-Catenine as a genomic target of high-grade microsatellite instability in colorectal cancer Verh. Dtsch. Ges. Pathol. 84:182-6.

Tuccari, G., Giuffre, G., Ofner, D. and Rüschoff J. (2000) Standardized use of the AgNOR method. J. Oral Pathol. Med. 29(10):526-7.

Vogel, P., Rüschoff, J., Kummel, S., Zirngibl, H., Hofstadter, F., Hohenberger, W. and Jauch, K.W. (2000) Prognostic value of microscopic peritoneal dissemination: comparison between colon and gastric cancer. Dis. Colon. Rectum. 43(1):92-100.

Kullmann, F., Widmann, T., Kirner, A., Justen, H.P., Wessinghage, D., Dietmaier, W., Rüschoff, J., Gay, S., Scholmerich, J. and Muller-Ladner, U. (2000) Microsatellite analysis in rheumatoid arthritis synovial fibroblasts. Ann. Rheum. Dis. 59(5):386-9.

Plaschke, J., Kruppa, C., Tischler, R., Bocker, T., Pistorius, S., Dralle, H., Rüschoff, J., Saeger, H.D., Fishel, R. and Schackert, H.K. (2000) Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer. Int. J. Cancer. 85(5):606-13.

Weitere Schlüsselpublikationen

Bocker, T., Rüschoff, J. and Fishel, R. (1999) Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects. Biochim. Biophys. Acta. 1423(3):O1-O10. Review.

Dietmaier, W., Hartmann, A., Wallinger, S., Heinmöller, E., Kerner, T., Endl, E., Jauch, K.W., Hofstadter, F. and Rüschoff, J. (1999) Multiple mutation analyses in single tumor cells with improved whole genome amplification. Am. J. Pathol. 154(1):83-95.

Rüschoff, J., Wallinger, S., Dietmaier, W., Bocker, T., Brockhoff, G., Hofstadter, F. and Fishel, R. (1998) Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc. Natl. Acad. Sci. U S A. 95(19):11301-6.

Publikationen Dr. Thomas Henkel
Publikationen 2000-2003

Roenicke, V, Stoss, O., Szado, T., Leclair, S., Kirsch, T., Hoffmann, A., Navé, B.T. and Henkel, T. (2003) Emerging molecular targets for chronic heart failure (Part II). Exp. Opinion Therap.Targets 7(1): 49-59

Roenicke, V, Stoss, O., Szado, T., Leclair, S., Kirsch, T., Hoffmann, A., Navé, B.T. and Henkel, T. (2002) Emerging molecular targets for chronic heart failure (Part I). Exp.Opinion Therap.Targets 6(6):649-658

Stoss, O., Reuner, B. and Henkel, T. (2002) RNA Expression profiling in cardiac tissue – a successful route to new drug targets? Targets 1, 12-19

Nave, B.T., Becker, M., Roenicke, V., Henkel, T. (2002) Validation of targets and drug candidates in an engineered three-dimensional cardiac tissue model. Drug Discov Today 7(7):419-425

Funk, M., Niedenthal, R., Mumberg, D., Brinkmann, K., Rönicke, V. and Henkel, T. (2002)

Vectors systems for the heterologous expression of proteins in Saccharomyces cerevisiae. In Guide to Yeast Genetics and Molecular Cell Biology Part B, Methods in Enzymology, Vol 350: 248

Weitere Schlüsselpublikationen

Henkel, T., Ling, P.D., Hayward, S.D. and Peterson, M.G. (1994) Mediation of Epstein-Barr Virus EBNA2 trans-activation by Recombination Signal-Binding Protein Jκ. Science, 265, 92 - 95.

Baeuerle, P.A. and Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.

Groß, N. A., Henkel, T., Karabinos, A., Götz, H., Barnikol-Watanabe, S. and Hilschmann, N. (1994) Human protein NEFA, a novel DNA binding/EF-hand/ leucine zipper protein - Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein. Biol. Chem. Hoppe Seyler, 375, 497-512

Henkel, T., Machleidt, T., Alkalay I., Krönke M., Ben-Neriah, Y. and P.A. Baeuerle

(1993) Rapid proteolysis of IκB-a is necessary for activation of transcription factor NF-κB. Nature 365, 182-185

Henkel, T., Zabel, U., van Zee, K., Müller, J., Fanning, E. and Baeuerle, P.A. (1992) Intramolecular masking of the nuclear location signal and dimerization domain in the precursor of the p50 NF-κB subunit. Cell 68, 1121-1133

Ruben, S., Dillon, P.J., Schreck, R., Henkel, T., Chen, C.-H., Maher, M., Baeuerle, P.A. and Rosen C. (1991). Isolation of a rel- related human cDNA that potentially encodes the 65-kD subunit of NF-κB Science 251: 1490-149

Publikationen Dr. Ernst Heinmöller

Heinmöller, E., Schlake, G., Renke, B., Liu, Q., Hill, K.A., Sommer, S.S. and Rüschoff, J. (2002) Microdissection and molecular analysis of single cells or small cell clusters in pathology and diagnosis--significance and challenges. Anal. Cell Pathol. 24(4-5): 125-34.

Heinmöller, E., Liu, Q., Sun, Y., Schlake, G., Hill, K.A., Weiss, L.M. and Sommer, S.S. (2002) Toward efficient analysis of mutations in single cells from ethanol-fixed, paraffin-embedded, and immunohistochemically stained tissues. Lab Invest. 82(4): 443-53.

Heinmöller, E., Renke, B., Beyser, K., Dietmaier, W., Langner, C. and Rüschoff, J. (2001) Piffalls in diagnostic molecular pathology--significance of sampling error.
Virchows Archiv 439(4): 504-11.

Kunishige, M., Hill, K.A., Riemer, A.M., Farwell, K.D., Halangoda, A., Heinmöller, E., Moore, S.R., Turner, D.M. and Sommer, S.S. (2001) Mutation frequency is reduced in the cerebellum of Big Blue mice overexpressing a human wild type SOD1 gene.
Mutat. Res. 473(2): 139-49.

Heinmöller, E., Dietmaier, W., Zirngibl, H., Heinmöller, P., Scaringe, W., Jauch, K.W., Hofstadter, F. and Rüschoff, J. (2000) Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma. Am. J. Pathol. 157(1): 83-92.

Dietmaier, W., Hartmann, A., Wallinger, S., Heinmöller, E., Kerner, T., Endl, E., Jauch, K.W., Hofstadter, F. and Rüschoff, J. (1999) Multiple mutation analyses in single tumor cells with improved whole genome amplification. Am. J. Pathol. 154(1): 83-95.

Heinmöller, E., Weinel, R.J., Heidtmann, H.H., Salge, U., Seitz, R., Schmitz, I., Muller, K.M. and Zirngibl, H. (1996) Studies on tumor-cell-induced platelet aggregation in human lung cancer cell lines. J. Cancer Res. Clin. Oncol. 122(12) :735-44.

Am Institut angefertigte Diplom- und Doktorarbeiten

Kaupisch, A. (2003) Einfluss von Fixationsbedingungen auf Biomarker in der Onkologie. Diplomarbeit, Fachbereich Naturwissenschaften, Universität Kassel.

Werther, M. (2003) Molekulargenetische Analysen von Vorläuferläsionen des Barrett Adenokarzinoms des Ösophagus im zeitlichen Verlauf. Diplomarbeit, Fachbereich Naturwissenschaften, Universität Kassel.

Zielinski, D. (2002) Quantifizierung der Expression der humanen Reparatur-Gene hMLH1 und hMSH2 mittels RT-PCR zur Diagnostik des hereditären nicht-polypösen Kolonkarzinoms. Diplomarbeit, Fachbereich Biologie, Universität Kassel.

Schmidtgen, C. (2002) Expressionanalyse von Prädiktoren der Chemoresponse bei Karzinomen. Doktorarbeit, Fachbereich Biologie, Universität Kassel.

Haneke, T. (2001) Isolierung und Analyse mikordisseminierter Tumorzellen in Lymphknoten bei kolorektalem Karzinom. Diplomarbeit, Fachbereich Biologie, Universität Kassel.

Renke, B. (2001) Das lymphatische Gewebe des Pharynx und des Cavum nasi bei verschiedenen Mammalia unter besonderer Berücksichtigung des Menschen. Doktorarbeit, Fachbereich Biologie, Universität Kassel.

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